Selasa, 29 April 2008

Cancer and animals

Cancer experiment on monkey

Cancer relates to questions of animal ethics in two major ways:

1) Animal experimentation

2) Human nutrition and lifestyle.


Let’s start with animal experimentation. This broad field branches out into two main areas in association with cancer:

a) animal testing of carcinogenicity (cancer-inducing quality) of substances

b) cancer research on animals to find cures for humans.


Animal testing of carcinogenicity


Carcinogenicity studies on animals are used for all kinds of compounds, in particular synthetic substances, pesticides, food additives and all sorts of other chemicals. They, especially pesticides tests, have been largely instigated by the environmentalist movement, which has created, since Rachel Carson’s book Silent Spring onwards, a public hysteria about a phantasmic connection between human cancer and man-made chemical substances in the environment.

The crude reality is that animal tests are a totally inadequate means of finding out whether a substance causes cancer in human subjects not just because of the important obstacle represented by species difference but also, more specifically, because of the extremely high dosages to which lab animals are subjected over a short period of time, as opposed to the low levels (mostly residues) to which humans are exposed over a long time.

Half of all the substances administered to animals at these near-toxic levels are carcinogenic in the test subjects, purely because of the local damage they cause in virtue of their massive amounts. Many of these chemicals are well-known for not causing cancer in humans at all.

What increases the risk of cancer in humans is something completely different, and we’ll get to that when we later discuss nutrition and lifestyle.

Of all the substances in our environment, one of the most seriously and lethally carcinogenic is asbestos, and here animal experiments have continuously misled researchers into believing that asbestos was safe simply because lab animals subjected to it did not develop the deadly form of cancer that we have known for decades to plague asbestos workers: mesothelioma. So, thanks to animal research, legislative measures to ban asbestos were delayed in the West by several decades, while workers and their families kept getting ill with asbestosis and tumors which could not be replicated in animals and therefore, so researchers thought, animal experiments had not “validated” the asbestos-mesothelioma causal connection.


Cancer research on animals


Cancer research on animals consists in taking healthy animals, mostly rodents, and trying to make them ill with cancer by various artificial means, sometimes successfully and sometimes not, in order to test on them possible treatments designed for humans. When researchers “luckily” succeed in making a healthy animal develop cancer, the tumor is not the same as the human one that it is supposed to model.

First of all, the aetiology of the disease is completely different. The causal mechanisms that induce cancer in humans are practically impossible to reproduce in a lab using animals. The most frequent causes of human cancer by far, as we shall see in more detail when we examine lifestyle, are smoking habits, bad nutrition choices, alcohol-drinking, lack of exercise, and all of these causal factors accumulate over a long period of time, often a lifetime, gradually and slowly. Lab animals, on the other hand, have to be made sick quickly, and they do not naturally indulge in all those cancer-risky lifestyle habits of which so many humans are so fond. So the means to induce cancer in them are necessarily artificial, different from the human causes, and designed to produce a rapid response.

Some common human cancers, like prostate, rectal and colon cancers, are rare in rats and mice, the cancer researchers’ favourite (most used) species. So experimenters have to labour particularly hard to inflict these tumours on rodents.

Regardless of the causes, moreover, cancer is not the same disease in different species of animals, human included. Cancer is not, strictly speaking, a disease, but an umbrella encompassing several ailments, according to the distribution of the various cancer sites. But animal tumours are not the same entities as human ones, even when they affect the same sites or are given, for reasons of convenience, the same name.

For instance, human bowel cancer affects a different part of the intestines (the colon or large bowel) from rats’ bowel cancer (the small bowel). And the mechanism of colon cancer in the two species is dissimilar: humans die because the cancer metastasizes, namely spreads to other parts of the body, whereas rats die because the colon is obstructed.

So, basically cancer researchers are studying something completely different when they use animals. The latter are not models of human cancer at all.

As a consequence, it should come as no surprise to learn that many of the various cancer treatments making the headlines, which have been tested on animals and found to be effective in them, turn out to be, when later administered to human subjects, ineffective or even harmful.



Human nutrition and lifestyle


We do not yet know how to cure cancer. Despite some improvement in therapy, this often fatal disease remains elusive to understand and refractory to cure. However, we know an awful lot about the risk factors that increase the probability of contracting cancer. Of all the areas of cancer research, the greatest progress has been made in cancer prevention. To stop cancer from developing in the first place remains the best option that we have.

And this, from many viewpoints (except perhaps if you consider laziness, addiction and force of habit), is extremely good news. Because all the major causes, or risk factors, of cancer are entirely under an individual’s control. They all pertain to a person’s lifestyle.

First comes tobacco, by far the major contributing factor to cancer incidence rates.

Then comes diet. We know very well what a cancer-preventing nutrition (and preventing other major diseases too) should be. Medical authorities and health experts advice is simple: avoid completely certain kinds of meat (namely, cured or processed meats like bacon and sausages), eat as little red meat as possible, reduce all types of meat and animal fats, replace them with proteins and fats of vegetable origin, and eat more fresh fruits, vegetables and grains.

And here we come to the other connection between cancer and animal ethics.

It looks like both our health and our morals point in the same direction. There is no real conflict of interests: what is good for us is also good for other animals, who could be spared the life-long torture of imprisonment in factory farms and the short but agonizing experience of the slaughterhouse.

Minggu, 27 April 2008

8 Skinny Habits To Lose Weight Naturally

A few weeks ago, one of my friends mentioned that she is considering taking a pill to reduce her weight. You must also have seen some convincing television advertisements that promise to get you in shape, and make look marvelous. I am generally not the type of person who falls for such things and, I couldn't believe that my friend was even considering such thing. I take pills (for ailments) only when the doctor forces it upon me! (If I can do without it, I would be the happiest.) So naturally, I was alarmed by what my friend said. I don't believe that there is a magic pill out there, which will reduce several dress sizes without any side effects!

Over the past few weeks I have been reading a fair bit on weight loss. I wanted to find out whether there are easier, less painful ways to lose weight and keep it off. To be honest, I didn't learn anything new. They were all things I had heard before. However, I believe they are all timely reminders everyone can try and persist with.

I managed to persuade my friend that a few simple life style changes might be all she needs. So this post is dedicated to her, and anyone else who would attempt to lose weight naturally.

#1.Practicing pang prevention

I read that researchers at Loughborough University found that people who ran before breakfast and pushed themselves physically were less hungry for two hours after eating than those who hadn’t exercised.

I volunteered to run with my friend on weekends. When I went to her house the first day, she was trying out her athletic shoes as if she was wearing them for the first time. I wasn’t surprised that the Adidas shoes she bought three years ago still looked brand new! On the other hand, my worn out discount athletic shoes weren’t branded.

#2.Make Porridge for breakfast

I have been eating porridge for breakfast for about 2 years now. What initially began as a weight reduction method has now become a part of my daily habit. Believe me, it will make you feel three times fuller than eating a croissant!

#3.Eat lots of fiber

A high fiber diet is one of the best ways to lose weight. Whole grain breads, berries such as blackberries, blueberries ..., almonds, flaxseed, broccoli, green peas and other dark green leafy vegetables are a few suggestions.

#4. Drink more water

We often consume a large amount of our daily calories from our sugary drinks. Try replacing your diet soda or coke with water. Initially this might be bit of a bore, but after you get used to it you won’t really feel that you are giving up anything. Also, a glass of water before your meals will even help you feel full. That way you eat less at every meal.

#5. Put less on your plate

Reduce portion sizes by 10% and you will lose weight without going hungry.

#6.Check you medicine cabinet

"Weight gain is a side effect of many drugs" says author of The Pill Book, Harold Silverman. Weight gainers include SSRI antidepressants, antihistamines and corticosteroids for asthma and allergies. Don’t stop taking any medication but do ask your doctor about changing your dose or an alternate.

#7. Only drink on 'weekends and wednesdays'!

Alcohol is full of empty calories that can't be stored. So the body uses them first, and then stores as fat anything else you're eaten surplus to your body's requirements.

#8. Watch less TV

The only two things that burn less calories than watching TV are sleeping and being dead. Be warned: 25% of people who watch two hours of TV a day are obese, as are 70% of those who watch three to five hours.
"The only way to lose fat is to take in fewer calories than your body needs. It's as simple as that." Anita Bean, nutritionist

Related Posts
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Sabtu, 26 April 2008

Carcinogenicity studies on animals


This page has moved here:


Carcinogenicity Studies on Animals













Some Boundaries to Freedom of Expression - Defamation, Slander, Libel, Malicious Falsehood

INTRODUCTION TO SOME OF THE BOUNDARIES
OF FREEDOM OF EXPRESSION
(Defamation, Slander, Libel, Malicious Falsehood, etc)

In law, defamation (also called vilification, slander, and libel) is the communication of a statement that makes a false claim, expressively stated or implied to be factual, that may harm the reputation of an individual, business, product, group, government or nation. Slander refers to spoken comments, while libel refers to any other form of communication such as written words or images. Most jurisdictions allow legal actions, civil and/or criminal, to deter various kinds of defamation and retaliate against groundless criticism. Related to defamation is public disclosure of private facts arises where one person reveals information which is not of public concern, and the release of which would offend a reasonable person. "Unlike libel or slander, truth is not a defense for invasion of privacy." http://en.wikipedia.org/wiki/Defamation


* * *

The aim of British libel laws is to balance the right of free speech against protection for the reputation of an individual from unjustified attack.

According to Sahota Solicitors at
http://www.libel-law.co.uk/

A person is libelled if the words expose him or her to the risk of being:

  • hated, ridiculed, or viewed with contempt, or
  • shunned or avoided, or
  • lowered in the standing of right thinking members of society, or
  • discredited in his trade, business, office, or profession.

Libel laws explained

http://www.guardian.co.uk/technology/2006/aug/31/news.politicsandthemedia


* * *


Russia Takes a Stand on Slander and Libel

On Friday 25 April Russia's lower house of parliament voted to widen the definition of slander and libel and give regulators the authority to shut down media outlets found guilty of publishing such material. The bill was approved nearly unanimously, but it faces additional votes before becoming law. The bill allows authorities to suspend and close down media outlets for libel and slander — punishment that is identical for news media found to be promoting terrorism, extremism and racial hatred.

It has also expanded the definition for slander and libel to "dissemination of deliberately false information damaging individual honor and dignity."

What has caused Russia to take a stand?

Paper is shut down after report on Vladimir Putin’s love life - http://www.timesonline.co.uk/tol/news/world/europe/article3779901.ece

President Putin denies affair with Kremlin 'babe' Alina Kabaeva - http://www.timesonline.co.uk/tol/news/world/europe/article3773353.ece

* * *

My blood relations and their associates are guilty of Defamation, Slander, Libel and Malicious Falsehood. There is obviously a reason for such communications against a blood relation - They want to cover up their own crimes and allegiances, which I will expose in the interests of everyone in society.

Selasa, 22 April 2008

Bloggers Unite

Bloggers Unite

Bloggers Unite is an initiative designed to harness the power of the blogosphere to make the world a better place. By challenging bloggers to blog about a particular social cause on a single day, a single voice can be joined with thousands of others to help make a real positive difference; from raising awareness for cancer, to an effort to better education systems or support 3rd world countries.

Minggu, 20 April 2008

Everyone Says It, Only A Few Talk About It

A few years ago, my father was very ill and had to undergo brain surgery. It was emotionally a very difficult period for my family and me. Through out the ordeal, my colleagues at work and my friends were very supportive.

At the time though, there were two common questions I had to deal with frequently.
"How is your father doing?"
"How are you coping?"

I know that most people who asked those questions meant well. The painful truth was that my father wasn’t doing well. He had a progressive disease and every day it seem to get a little worse. Seeing my father suffer was oh so agonizing to watch. I felt empty. I felt angry. I felt alone. I had so many "Why Lord" questions. To my family, I put a steady front. They too were finding it difficult. I knew that I had to “pull it together” for their sake. Even though I have many friends, I could only tell how I actually felt to two of my closest friends. To everyone else, I tried to force a smile and mutter something far away from the how I actually felt.

Going back to those two questions, to some people, it was just their way of making small talk. For others it was getting an update on the latest news. The rest, I believe asked out of guinea concern. I still wonder what others would have thought about me had I told how I actually felt.

Anyway, my father came through the surgery. Little by little, he started going every day tasks he couldn’t do before. He was progressing well. At this stage, I gave everyone the same answer; the positive news.

May be you have not faced such a catastrophic situation. (I don’t wish upon anyone such misery.) However, there is one question that I know for sure that you have been asked at least once in your lifetime.

"How are you?" Again, used for just conversation sake, curiosity or actual concern. This question is generally following by "I am ok", "Fine that you" etc. What you if you feel really down and you are not ok. How would people react if you reply "I am not ok". Can you imagine going for an interview and giving such answer!

When faced with such questions, in my book there are two approaches of answering them. I am sure you didn’t give it much thought before. It all comes down to
The way you actually feel
What people want to hear (positive side!)

So how are you doing today? You don’t have to be fine ;-)

This was one of my thinking out loud posts. I would like to hear your thoughts. Do you say what people expect you to say? Or answer how you actually feel?

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Are We There Yet?
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Kamis, 17 April 2008

Motivation Boost To Keep You Strong-It Will Come

Poem By Nathan Watson

When life's largest pressures leave you struck dumb,
Just search for an answer; the solution will come.

When a tragedy occurs leaving you feeling numb,
Just wait for your health; the strength will come.

When everyone relies on you and there is no way you can see,
Trust your mind to think with time; patience is the key.

When you have made it where others always flee,
Just wait to gather courage; soon you'll be where you want to be.

When it is nearing the end and you're in need,
Muster up your courage; endurance will lead.
IT WILL COME

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Moments In Life

Senin, 14 April 2008

Give Up The Guilt. You’re Not A Bad Person

Whether it is regretting that credit card splurge, agonizing about not returning your friend’s call or feeling remorse for not spending more time with your children or [insert your current guilty feeling here]... or worse...

Guilt hovers over you like a dark cloud. Thoughts seem to have a mind of their own, intruding at all hours of the day. Chances are that sometimes we feel guiltier than the inmates of Wormwood Scrubs!
So next time, the Judge Judy in your head goes into overdrive, follow these tips- and banish those bad feelings for good. (Well, I am trying to be positive here. Stay with me!)

#1. Stop beating yourself up
Ok. So you might have not done the right thing when it was required, but that doesn’t make you a monster. Instead of punishing yourself, and focusing on all the terrible things you think you’ve done, remember some of your good deeds.

#2. Do it for you
It might be trying to lose weight, feeling you should work late to please your boss or fretting about spending more quality time with the kids, but chances are there’s always something you think you should be doing. Living up to other people’s expectations leaves you wracked with feelings of guilt and inadequacy.
Ask yourself, what YOU want. The minute you realize your guilt comes from a perceived failure to live up to other people’s expectations, it will gradually disappear.

#3. Apologies
Sometimes, there’s a good reason for feeling guilty; like forgetting your anniversary, or forgetting to call your Mum on Mother’s day for example.

If your guilt is rational, then try to apologies as soon as possible. An honest apology will make the person you’ve upset feel better. (It might take a long time for them to forgive and forget though!)
Putting it off the apology will only intensify your feelings and you’ll waste energy fretting about it.

#4. Be a Do-Gooder
With so many atrocities going on in this world, it's easy to feel guilty about your own good fortune. We can’t always right every wrong. So try focusing on the little things you can change. You can do for other’s what they can't do for themselves.

It might not be enough to save the world, but it will soothe your conscience not knowing that at least you’re doing your bit.

#5. See the flip side
Begin appreciating what you’ve got instead of stressing about what you haven't got (I know this is easier said than done). There are always two sides to every story ;-)

#6. Get it off your chest
Sometimes the best thing is to talk it out. Tell someone you can confide in about your guilt.


Related Posts
6 Timeless Ways To Stay Out Of Trouble
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Tame Your Temper; 6 Tips That Actually Work
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Sabtu, 12 April 2008

Human Rights and Some Boundaries - I have Done My Duty!

HUMAN RIGHTS AND SOME BOUNDARIES - I HAVE DONE MY DUTY!


SOME OF THE ARTICLES FROM THE UDHR, ECHR AND UKHR, SIDE BY SIDE FOR COMPARATIVE PURPOSES

Freedom can only be GIVEN to rational and responsible people who Care about boundaries and Recognize the consequences of their own actions on people and society, as a whole. Some people do not care. Some people are also completely void of Common Sense, as adults. When the boundaries of civilized communications and behaviour are crossed, highly adverse consequences can ensue such as verbal and physical attacks, injury and even loss of human life.

This post identifies some of the articles in the UDHR along with the equivalent articles in the ECHR and UKHR act. I have focused on these articles because of the actions of my own blood relations and their associates.


SLAVERY & SERVITUDE


UDHR1948 - Article 4.
No one shall be held in slavery or servitude; slavery and the slave trade shall be prohibited in all their forms.

ECHR1950 - Article 4 . Prohibition of slavery and forced labour
UKHR1998 - Article 4 - Prohibition of slavery and forced labour
(same text as ECHR1950)

1. No one shall be held in slavery or servitude.
2. No one shall be required to perform forced or compulsory labour.
3. For the purpose of this Article the term “forced or compulsory labour” shall not include:
(a) any work required to be done in the ordinary course of detention imposed according to the provisions of Article 5 of this Convention or during conditional release from such detention;
(b) any service of a military character or, in case of conscientious objectors in countries where they are recognised, service exacted instead of compulsory military service;
(c) any service exacted in case of an emergency or calamity threatening the life or well-being of the community;
(d) any work or service which forms part of normal civic obligations.



FREEDOM OF THOUGHT, CONSCIENCE & RELIGION

UDHR1948 - Article 18.
Everyone has the right to freedom of thought, conscience and religion; this right includes freedom to change his religion or belief, and freedom, either alone or in community with others and in public or private, to manifest his religion or belief in teaching, practice, worship and observance.

ECHR1950 - Article 9 . Freedom of thought, conscience and religion
UKHR1998 - Article 9 - Freedom of thought, conscience and religion
(same text as ECHR1950)
1. Everyone has the right to freedom of thought, conscience and religion; this right includes freedom to change his religion or belief and freedom, either alone or in community with others and in public or private, to manifest his religion or belief, in worship, teaching, practice and observance.
2. Freedom to manifest one’s religion or beliefs shall be subject only to such limitations as are prescribed by law and are necessary in a democratic society in the interests of public safety, for the protection of public order, health or morals, or for the protection of the rights and freedoms of others.

NOT A FREEDOM To Engage in Hate Crimes - based on race, religion, sexual orientation, disability, ethnicity, nationality, age, gender, gender identity, or political affiliation. Religious Affiliations are based on Personal Choice upon reaching the Age Of Majority (18) and not the Identity of Parents and Baptism as a child.


FREEDOM OF OPINION & EXPRESSION

UDHR1948 - Article 19.
Everyone has the right to freedom of opinion and expression; this right includes freedom to hold opinions without interference and to seek, receive and impart information and ideas through any media and regardless of frontiers.

ECHR1950 - Article 10 . Freedom of Expression
UKHR1998 - Article 10 - Freedom of Expression
(same text as ECHR1950)
1. Everyone has the right to freedom of expression. This right shall include freedom to hold opinions and to receive and impart information and ideas without interference by public authority and regardless of frontiers. This Article shall not prevent States from requiring the licensing of broadcasting, television or cinema enterprises.
2. The exercise of these freedoms, since it carries with it duties and responsibilities, may be subject to such formalities, conditions, restrictions or penalties as are prescribed by law and are necessary in a democratic society, in the interests of national security, territorial integrity or public safety, for the prevention of disorder or crime, for the protection of health or morals, for the protection of the reputation or rights of others, for preventing the disclosure of information received in confidence, or for maintaining the authority and impartiality of the judiciary.

NOT A FREEDOM
:
Defamation (slander and libel), Obscenity, Threats, Lying in court (perjury), contempt of court, Limit the size of public demonstrations, Profanity, Hate speech that is defamatory or causes incitement to violence, Deliver lies to a crowd causing panic, Clear and present danger or Imminent lawless action, such as shouting fire in a crowded theater.

NOT A FREEDOM
to prevent Valid Legal Action and Pervert the Course of Justice through defamation and threats;
to stop people from receiving and imparting information to the authorities.



FREEDOM OF ASSEMBLY & ASSOCIATION
UDHR1948 - Article 20.
(1) Everyone has the right to freedom of peaceful assembly and association.
(2) No one may be compelled to belong to an association.

ECHR1950 - Article 11 . Freedom of assembly and association
UKHR1998 - Article 11 - Freedom of assembly and association
(same text as ECHR1950)
1. Everyone has the right to freedom of peaceful assembly and to freedom of association with others, including the right to form and to join trade unions for the protection of his interests.
2. No restrictions shall be placed on the exercise of these rights other than such as are prescribed by law and are necessary in a democratic society in the interests of national security or public safety, for the prevention of disorder or crime, for the protection of health or morals or for the protection of the rights and freedoms of others. This Article shall not prevent the imposition of lawful restrictions on the exercise of these rights by members of the armed forces, of the police or of the administration of the State.




RESPECT FOR PRIVATE AND FAMILY LIFE

UDHR1948 - Article 12.
No one shall be subjected to arbitrary interference with his privacy, family, home or correspondence, nor to attacks upon his honour and reputation. Everyone has the right to the protection of the law against such interference or attacks.
ECHR1950 - Article 8 . Right to respect for private and family life
UKHR1998 - Article 8 - Right to respect for private and family life
(same text as ECHR1950)
1. Everyone has the right to respect for his private and family life, his home and his correspondence.
2. There shall be no interference by a public authority with the exercise of this right except such as is in accordance with the law and is necessary in a democratic society in the interests of national security, public safety or the economic well-being of the country, for the prevention of disorder or crime, for the protection of health or morals, or for the protection of the rights and freedoms of others.

NOT A FREEDOM - To deny self determination of family members who have reached the age of majority/maturity and to obtain confidential information about a blood relation who has reached the age of majority/maturity. To interfere and destroy employment and work relations, as well as jeopardize financial security.



PROHIBITION OF ABUSE OF RIGHTS

UDHR1948 - Article 30.
Nothing in this Declaration may be interpreted as implying for any State, group or person any right to engage in any activity or to perform any act aimed at the destruction of any of the rights and freedoms set forth herein.

ECHR1950 - Article 17 . Prohibition of abuse of rights (same text as ECHR1950)
UKHR1998- Article 17 - Prohibition of abuse of rights
Nothing in this Convention may be interpreted as implying for any State, group or person any right to engage in any activity or perform any act aimed at the destruction of any of the rights and freedoms set forth herein or at their limitation to a greater extent than is provided for in the Convention.

____________________________________________________________________

I DID MY DUTY in 1994 (one more job)!

Jumat, 11 April 2008

Thalidomide tragedy, side effects, history

Drug testing on animals













What is Thalidomide


Thalidomide was one of the greatest cases in history of a drug disaster tragedy being caused by animal research.

First of all, Thalidomide had been tested on animals extensively prior to its marketing.

Even now, despite the clinical evidence to the contrary, British health authorities like the Medical Research Council maintain that the vast bulk of evidence from laboratory and animal tests is against thalidomide having any genetic effects.

The tragedy caused by Thalidomide in the 1960s was due to its teratogenic effects, ie effects on the foetus. Teratological effects of drugs were little known then. They were brought to public attention because of the Thalidomide tragedy on humans, therefore only after it. How on earth could animal researchers have thought of those effects before the disaster?

Even after the Thalidomide caused birth deformities in humans, researchers tried to reproduce the same effect in dozens of species of lab animals without success.

Take a look:

"As a consequence to the thalidomide tragedy there has been a marked upsurge in the number of animals used in testing of new drugs. Also drugs are now specifically tested on pregnant animals to supposedly safeguard against possible teratogenic effects on the human foetus. Vivisector's claim that if such tests were carried out prior to thalidomide's release, birth deformities in humans would have been discovered. This is of course sheer nonsense. 'In pregnant animals, differences in the physiological structure, function and biochemistry of the placenta aggravate the usual differences in metabolism, excretion, distribution and absorption that exist between species and make reliable predictions impossible.' (15) (Dr Robert Sharpe, former senior research chemist.)

"In fact when the link between human foetal abnormalities and thalidomide was established (through clinical observation), the world-wide explosion of animal testing, using a large range of species, proved very difficult to duplicate the abnormalities. (16) Writing in his book Drugs as Teratogens, J.L. Schardein observes: 'In approximately 10 strains of rats, 15 strains of mice, eleven breeds of rabbit, two breeds of dogs, three strains of hamsters, eight species of primates and in other such varied species as cats, armadillos, guinea pigs, swine and ferrets in which thalidomide has been tested teratogenic effects have been induced only occasionally.' (17) Eventually after administrating high doses of thalidomide to certain species of rabbit (New Zealand White) and primates could similar abnormalities be found. However researchers pointed out that malformations, like cancer, could occur when practically any substance, including sugar and salt, be given in excessive doses. (16)" [my emphasis]

Thalidomide's history in the USA


Some apologists of animal experimentation say that the reason why Thalidomide was never approved by the FDA (Food and Drugs Administration, the US agency responsible for drugs licensing) in the US is that the FDA reviewer had previous experience in animal research and had refused to clear the drug for sale until better documentation of its effects were provided.

The reality is that the FDA reviewer in question, Frances Oldham Kelsey, had doubts about Thalidomide's safety because of side effects shown in human clinical trials.

The FDA website is very clear on this. In Frances Oldham Kelsey: FDA Medical Reviewer Leaves Her Mark on History it says:

"In December of 1960, three months after Richardson-Merrell submitted its application, the British Medical Journal published a letter from a physician, Leslie Florence, who had prescribed thalidomide to his patients. Florence reported seeing cases of peripheral neuritis, a painful tingling of the arms and feet, in patients who had taken the drug over a long period of time." [emphases added]

And here is another biographical note on Frances Kelsey:

"Dr. Kelsey continued to resist, pointing out in February 1961 that a study in England had indicated the new product caused 'a serious side effect on the nervous systems of patients who took the drug repeatedly,' so she asked for assurances that such side effects wouldn't occur. By May she had developed a theory that if thalidomide caused paralysis of the peripheral nerves, the drug probably would cause greater damage to the developing embryo." [emphasis added]

Better control


The answer is: better control of the effects of medicines after they have been marketed.

"We need to encourage doctors and drug companies to watch for, report and take note of side effects in order to protect patients properly. If proper drug surveillance techniques had been available in the 1960s the thalidomide problem would have been picked up much earlier. We still don't have proper post marketing trials in place." (from the source above)

Testing on humans is going to happen anyway, because any new drug which is marketed is an unknown, due to the unreliability of previous animal testing.

Let me repeat: you cannot make an unreliable method reliable by counterexamples.

Even if you happen to encounter cases where animal tests results have not been refuted by their application to humans, this does not alter the unreliable status of the method.

There are cases where there is a correspondence between human and non-human animals. But how do we know that? Because we transferred the results of animal testing on humans. That is, for all practical purposes, we tested them on humans.

It is an unavoidable fact.

Kamis, 10 April 2008

Work Well From Home (Book Review)

An increasing number of people are deciding to work from home. Whether they are setting up their own business or trying to cut down on the amount of time they spend commuting, the idea of turning a space at home into and office is an appealing one.

Browsing Through Work Well from Home (Steps to Success)

Chapter 1: Deciding whether working from home would work for you
Working from home is an attractive option for many people, but there is clearly a lot to think about before you take the plunge. This chapter helps you identify whether working from home is a good option for you.

Chapter 2: Setting up your home office
Once you decide that working from home is the best option for you, you need to make it happen. Planning the layout of your office, getting the right equipment and insurance are what is covered here.

Chapter 3: Getting used to working from home
This chapter talks about creating boundaries, getting into a routine and creating a life balance.

Chapter 4: Learning to prioritize tasks
Keeping control of tasks is an essential skill to master, especially if you are working from home. The tips given here can be used as a framework to guide you to the variety you need, in your daily life.

Chapter 5: Maintain your relationships with the office and key contacts
When you are working from home you’re all the more likely to need a strong network to be as effective as you can in your work. This chapter gives advice on how to keep in touch with your contacts.

Chapter 6: Working as part of a virtual team
Members of a virtual team may all work for the same company, be a mix of employees and freelances, or be entirely freelance. Team members may be scattered across one country or all around the world. This chapter talks about how to build rapport with all your members and also the different roles in the team.

Chapter 7: Coping with feelings of isolation
The natural contacts of the daily commute, bumping into friends in the kitchen, going out for lunch or after-work activities may be things that you might need to give up. After some time you probably miss the social side of the working life.

Chapter 8: Setting up as a free agent
This chapter examines the reasons you would want to be a freelancer, and if you decide to do so how you can build your development plan.

My favorite excerpt
Create some boundaries
It’s hopeless trying to balance your laptop on your knee in the kitchen while you attempt to avoid intrusions from family and friends; you need to set rules for yourself and others so that everyone can support you efforts rather than sabotage them.
If there are other people at home, be clear about the time you set aside for working. Non-work interruptions can be frustrating when you are trying tog et something done to a deadline.

Overall

  • Is a small pocket size book which is cleanly written and presented.

  • Each chapter takes the same format of first presenting an introduction, followed by the tips, the common mistakes and useful links.

  • The links provided at the end of each chapter, and some tips given, led me to believe that this book is targeted towards the UK audience.

  • Is an ideal guide for someone who is contemplating the shift to work from home.


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HUMAN RIGHTS - Concepts, Philosophies, Organisations & Legal Instruments

HUMAN RIGHTS - Concepts, Philosophies, Organisations & Legal Instruments
These Links Go To Wikipedia Information Pages

CONCEPTS & PHILOSOPHIES

ORGANISATIONS

Multi-lateral bodies involved in human rights
European Union · Council of Europe · Organisation of American States · UNHCR · UNOCHA · International Labour Organization · WHO · UNESCO · UNAIDS · UNDESA · CSW · UNFPA · UNICEF · UNIFEM · UNDP · FAO · UN-HABITAT

LEGAL INSTRUMENTS

CONCEPTS THAT MAY BE CONSIDERED AS HUMAN RIGHTS

Separate the Genuine from the Fake

How to Differentiate between the Genuine and the Fake

A Genuine refugee/asylum seeker lives in Genuine Fear of returning to persecution (Reason of race, religion, nationality, political opinion or membership in a "social group”) therefore they will be grateful and respectful towards the state that provides refuge and protection. They will willingly comply with established laws and social normalities. They do not have reason to complain about living conditions (accommodation, food, health care, law and order, etc), which are clearly superior to the country they have fled from.

It is possible to determine when a foreigner has lied to obtain citizenship and they are an economic migrant. They will ignore state laws and socially acceptable behaviour, except of course, The Conditions of Employment and Payment.

Selasa, 08 April 2008

The greatest scientific event of the millennium

Toxicity test rabbitNever before have I had such a clear feeling that animal experimentation has its days counted, and that supporters of vivisection have started seeing the writing on the wall.

As important as penicillin, double helix and computers


The most prestigious scientific body in the world, which advises the US government on scientific issues, the National Research Council of the U.S. National Academy of Sciences, has released in June 2007 a report entitled “Toxicity Testing in the 21st Century: a Vision and a Strategy”.

The report was commissioned by the Environmental Protection Agency (EPA), another US federal body, responsible for thousands of safety (toxicity) tests on animals each year.

It is nothing short of revolutionary, and whoever knows the facts about animal experiments will realize its immense importance. Especially for people who know how much the American scientific establishment has historically been the most staunch supporter of animal research, this new report will be a blow.

The report’s authors convey very well its revolutionary meaning and the feeling that we have reached a turning point in biomedical research, in the very way they start it:

“Change often involves a pivotal event that builds on previous history and opens the door to a new era. Pivotal events in science include the discovery of penicillin, the elucidation of the DNA double helix, and the development of computers. All were marked by inauspicious beginnings followed by unheralded advances over a period of years but ultimately resulted in a pharmacopoeia of life-saving drugs, a map of the human genome, and a personal computer on almost every desk in today’s workplace.

Toxicity testing is approaching such a scientific pivot point. It is poised to take advantage of the revolutions in biology and biotechnology.”
[emphases added]

The report says:

“Advances in toxicogenomics, bioinformatics, systems biology, epigenetics, and computational toxicology could transform toxicity testing from a system based on whole-animal testing to one founded primarily on in vitro methods that evaluate changes in biologic processes using cells, cell lines, or cellular components, preferably of human origin.” [emphasis added]

Non-animal methods outperform animal tests


The superiority of non-animal methods of testing substances for toxicity to humans, compared to animal methods, is acknowledged by the report:

“The envisioned change is expected to generate more robust data on the potential risks to humans posed by exposure to environmental agents and to expand capabilities to test chemicals more efficiently. A stronger scientific foundation offers the prospect of improved risk-based regulatory decisions and possibly greater public confidence in and acceptance of the decisions.” [emphases added]

The report admits that the current animal method of testing has not been evaluated for its usefulness but rather used by inertia:

”The current system is the product of an approach that has addressed advances in science by incrementally expanding test protocols or by adding new tests without evaluating the testing system in light of overall risk-assessment and risk-management needs. That approach has led to a system that is somewhat cumbersome with respect to the cost of testing, the use of laboratory animals, and the time needed to generate and review data.” [emphases added]

There is acceptance in the report of the well-known problem that the extremely high levels of doses to which lab animals are subjected are a further element of unreliability and lack of predictive value of animal tests, given the huge discrepancy with the actual, much lower, doses of chemicals to which humans are exposed:

“Moreover, the vision will lead to a marked reduction in animal use and focus on doses that are more relevant to those experienced by human populations.” [emphasis added]

The report’s vision is that eventually non-animal strategies will completely replace animal-based toxicity tests and revolutionize safety testing.

The report recommends advanced non-animal methods using in vitro human cell lines in combination with computational methods and epidemiological studies. These new methods should also be employed in other areas of biomedical research currently using animals, and there is reason to hope that the new report may influence that development too.

The reference in the report to “paradigm shift” as the description for the new vision outlined there echoes Brute Science: Dilemmas of Animal Experimentation (Philosophical Issues in Science), a revolutionary book written by a philosopher and a biologist. The book uses science historian Thomas Kuhn’s concept of “paradigm” to explain the “sticky” nature of scientific enquiry, the prevailing scientific dogmatism which often makes change in normal scientific activity between “revolutions” so difficult. That echo seems to indicate that this report has taken on board criticisms made by the anti animal experimentation camp, to which the book generally belongs.

The future has already started


This milestone report comes at a crucial moment in the history of toxicity testing. The European Union has last year approved a new Regulation called REACH (Registration, Evaluation and Authorisation of Chemicals) which will require the largest mass animal testing programme in Europe’s history. It has just started and will see the testing of 30,000 chemicals on an estimated 10 to 50 millions animals.

This programme is closely watched by the US and the rest of the world as a pioneering enterprise. So it is the right moment for Europe to introduce the new methods and the new vision that this report so clearly recommends. Otherwise REACH could be an incalculable waste of money, time, resources without any benefit but possible harm to humans, and a totally pointless, immense source of animal suffering. Non-animal tests would provide more reliable data, produced more quickly and at an enormously lower cost than animal tests.

The “Toxicity Testing in the 21st Century: a Vision and a Strategy” report, which has the purpose of guiding future research policy, has already had a momentous application: a Memorandum of Agreement was signed by the Environmental Protection Agency, the National Toxicology Program and the National Institutes of Health on 14th February 2008 aiming to end animal testing of chemicals and drugs.

Another cause for much happiness is that the hugely influential anti-visection Italian-Swiss author, the great Hans Ruesch, who wrote Naked Empress or, the Great Medical Fraud and many other books on animal experimentation, was able to see what appears like the beginning of the end for animal experimentation before he died on 27th August 2007, aged 94. He started me on this path when I was 17 years old and read his books.

This post is also a tribute to his memory. He can rightly be called the founder of the modern scientifically-based anti-vivisection movement. We will continue the fight that he began.



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